Nanoparticle Characterization
Direct, decision-ready characterization of nanoparticles
Cryo-electron microscopy (cryo-EM) is the gold standard for nanoparticle characterization when direct visualization matters. Unlike indirect or bulk techniques, cryo-EM enables single-particle analysis of nanoparticles in their native state, revealing critical attributes that directly impact efficacy, safety, and developability.
TEMPoS offers automated nanoparticle characterization through a proprietary, AI-powered web platform — a secure, fully in-house tool designed for pharma, biotech and manufacturing teams to generate fast, reproducible, and decision-ready results. Unlike traditional CRO services, your team uses the platform directly, controlling the entire analysis workflow. The platform is delivered as a cloud-based SaaS, so no installation or EM image-analysis expertise is required.
Why Cryo-EM for nanoparticles?
Cryo-EM is the method of choice when you need:
- Direct visualization of individual particles (not averaged signals)
- Accurate assessment of drug load, size, shape, and morphology
- Detection of heterogeneity, aggregation, or malformed particles
- Native-state analysis without staining or dehydration artifacts
It is particularly relevant for AAVs, LNPs, VLPs, and advanced nanoparticle systems, where structural variability directly impacts performance.
Why the TEMPoS Web Platform?
Our proprietary AI-powered web platform transforms cryo-EM images into actionable quantitative insights with automatically generated reports, eliminating the need for EM or image-analysis expertise.
Key commercial benefits:
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- Full automation → eliminates manual, time-consuming, and subjective analyses
- Speed → results delivered in minutes, not days
- Cost efficiency → reduces outsourcing and internal analysis hours
- Reproducibility → consistent, bias-free outputs every time
- Autonomy → your team conducts analyses fully in-house
- Scalability → effortlessly handles large EM datasets
- Analytics & history → track analyses, monitor monthly throughput, and access statistics across samples
The platform is designed for formulation scientists, process development teams, and decision-makers, enabling faster, more confident go/no-go decisions while maintaining full traceability of your work.
See the TEMPoS Web Analysis tool in action — request a demo today.
Public funding acknowledgment
This activity is supported by IGAPE (Instituto Galego de Promoción Económica) under grant IG408M – Axudas para o Desenvolvemento Tecnolóxico e a Innovación mediante o uso da Intelixencia Artificial (2025), Liña A, focused on Análisis y Caracterización Automatizada de Nanopartículas en Cryo-EM”.
