Services
Years of experience, technical expertise and comprehensive capabilities make TEMPoS your trusted cryo-EM partner. Our seasoned team delivers a wide array of services, spanning from protein structure determination to consulting and training.
By synergizing our insights and skills, we can optimize your performance and boost your productivity, ensuring unparalleled results in your scientific endeavors. Unlock the full potential of cryo-EM with TEMPoS today.
About cryo-EM
Cryo-electron microscopy (cryo-EM) is transforming structural biology and nanomedicine by enabling direct visualization of biological macromolecules and nanoparticles in their native state. Samples are rapidly frozen and imaged without labeling or crystallization, preserving their real structure, heterogeneity, and interactions.
Cryo-EM is the method of choice when:
- Targets are difficult or impossible to crystallize
- Structural flexibility or multiple conformational states are biologically relevant
- Complex assemblies, membrane proteins, or large biomolecular systems are involved
- Direct visualization of nanoparticles is required, rather than indirect or averaged measurements
- Size, shape, heterogeneity, aggregation state, or payload distribution must be assessed at the single-particle level
Recognized with the 2017 Nobel Prize in Chemistry, cryo-EM has become a cornerstone technology for drug discovery and delivery. It helps teams:
- Accelerate R&D timelines and move faster toward patients
- Make structure-guided drug discovery more efficient and cost-effective
- Gain deeper insights into drug delivery systems and gene therapy vectors such as AAVs and LNPs
We combine cutting-edge cryo-EM technology with hands-on expertise and tailored workflows, from experimental design and workflow setup to data acquisition, processing, and analysis.
Whether it’s protein structures, nanoparticle characterization, or expert consulting, we work as an extension of your team to accelerate discovery and deliver actionable insights.
We deliver tailored cryo-EM solutions for:
For Drug Development
Protein Structure Determination Gain high-resolution cryo-EM structures of protein complexes to:
- Support rational drug and vaccine design
- Reveal biomolecular and ligand–protein interactions
- Understand molecular mechanisms
- Enable antibody epitope mapping
For Drug Delivery
Nanoparticle Characterization
Automated quantitative and qualitative analysis of nanoparticle formulations — including AAVs, LNPs, and other advanced systems — directly from EM images using our proprietary AI-powered web platform. Fast, reproducible, fully in-house, and accessible via secure SaaS, enabling your team to make confident and data-driven decisions.
Additional Support
Consulting & Training Strategic cryo-EM consulting and personalized guidance, including:
- Training and software setup
- EM facility design and optimization
- Operational and technical support